Novel Therapies for Neurodegenerative Diseases

Grant number: 1031193 | Funding period: 2012 - 2014

Completed

Abstract

Exitotoxicity has been implicated in many neurological disorders incluing Alzheimer's and Huntington's disesaes. This toxicity can be inhibited by modulated intracellular copper levels. Here we will ascertain the therapeutic potential of strategies designed to increase cellular copper levels.

Related publications (3)

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

S McKenzie-Nickson, J Chan, K Perez, LW Hung, L Cheng, A Sedjahtera, L Gunawan, PA Adlard, DJ Hayne, LE McInnes, PS Donnelly, DI Finkelstein, AF Hill, KJ Barnham

2018-11-21

Alzheimer's disease (AD) is the leading cause of dementia worldwide accounting for around 70% of all cases. There is currently no ..

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

LC Beauchamp, J Chan, LW Hung, BS Padman, LJ Vella, XM Liu, B Coleman, AI Bush, M Lazarou, AF Hill, L Jacobson, KJ Barnham

2018-07-05

Parkinson's disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic ..

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

T Johanssen, N Suphantarida, PS Donnelly, XM Liu, S Petrou, AF Hill, KJ Barnham

2015-09-01

Excitotoxicity is the pathological process by which neuronal death occurs as a result of excessive stimulation of receptors at the..

University of Melbourne Researchers

Kevin Barnham

Peter Crouch

Paul Donnelly